A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer; Caitrin W McDonough; Pamela J Hicks; Bong H Roh; Maria R Wing; S Sandy An; Jessica M Hester; Jessica N Cooke; Meredith A Bostrom; Megan E Rudock; Matthew E Talbert; Joshua P Lewis; Assiamira Ferrara; Lingyi Lu; Julie T Ziegler; Michele M Sale; Jasmin Divers; Daniel Shriner; Adebowale Adeyemo; Charles N Rotimi; Maggie C Y Ng; Carl D Langefeld; Barry I Freedman; Donald W Bowden; Benjamin F Voight; Laura J Scott; Valgerdur Steinthorsdottir; Andrew P Morris; Christian Dina; Ryan P Welch; Eleftheria Zeggini; Cornelia Huth; Yurii S Aulchenko; Gudmar Thorleifsson; Laura J McCulloch; Teresa Ferreira; Harald Grallert; Najaf Amin; Guanming Wu; Cristen J Willer; Soumya Raychaudhuri; Steve A McCarroll; Claudia Langenberg; Oliver M Hofmann; Josée Dupuis; Lu Qi; Ayellet V Segrè; Mandy van Hoek; Knut Borch-Johnsen; Kirsten Ohm Kyvik; DIAGRAM Consortium

doi:10.1371/journal.pone.0029202

A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer, Caitrin W McDonough, Pamela J Hicks, Bong H Roh, Maria R Wing, S Sandy An, Jessica M Hester, Jessica N Cooke, Meredith A Bostrom, Megan E Rudock, Matthew E Talbert, Joshua P Lewis, Assiamira Ferrara, Lingyi Lu, Julie T Ziegler, Michele M Sale, Jasmin Divers, Daniel Shriner, Adebowale Adeyemo, Charles N RotimiMaggie C Y Ng, Carl D Langefeld, Barry I Freedman, Donald W Bowden, Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira, Harald Grallert, Najaf Amin, Guanming Wu, Cristen J Willer, Soumya Raychaudhuri, Steve A McCarroll, Claudia Langenberg, Oliver M Hofmann, Josée Dupuis, Lu Qi, Ayellet V Segrè, Mandy van Hoek, Knut Borch-Johnsen, Kirsten Ohm Kyvik, DIAGRAM Consortium

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

Originalsprog	Engelsk
Artikelnummer	e29202
Tidsskrift	PLoS ONE
Vol/bind	7
Udgave nummer	1
DOI	https://doi.org/10.1371/journal.pone.0029202
Status	Udgivet - 2012

Adgang til dokumentet

10.1371/journal.pone.0029202

Citationsformater

Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., ... Consortium, DIAGRAM. (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE , 7(1), Artikel e29202. https://doi.org/10.1371/journal.pone.0029202

@article{0c89fc10d0124c79887a1f02c220c55e,

title = "A genome-wide association search for type 2 diabetes genes in African Americans",

abstract = "African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P",

keywords = "Adult, African Americans, Aged, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Validation Studies as Topic",

author = "Palmer, \{Nicholette D\} and McDonough, \{Caitrin W\} and Hicks, \{Pamela J\} and Roh, \{Bong H\} and Wing, \{Maria R\} and An, \{S Sandy\} and Hester, \{Jessica M\} and Cooke, \{Jessica N\} and Bostrom, \{Meredith A\} and Rudock, \{Megan E\} and Talbert, \{Matthew E\} and Lewis, \{Joshua P\} and Assiamira Ferrara and Lingyi Lu and Ziegler, \{Julie T\} and Sale, \{Michele M\} and Jasmin Divers and Daniel Shriner and Adebowale Adeyemo and Rotimi, \{Charles N\} and Ng, \{Maggie C Y\} and Langefeld, \{Carl D\} and Freedman, \{Barry I\} and Bowden, \{Donald W\} and Voight, \{Benjamin F\} and Scott, \{Laura J\} and Valgerdur Steinthorsdottir and Morris, \{Andrew P\} and Christian Dina and Welch, \{Ryan P\} and Eleftheria Zeggini and Cornelia Huth and Aulchenko, \{Yurii S\} and Gudmar Thorleifsson and McCulloch, \{Laura J\} and Teresa Ferreira and Harald Grallert and Najaf Amin and Guanming Wu and Willer, \{Cristen J\} and Soumya Raychaudhuri and McCarroll, \{Steve A\} and Claudia Langenberg and Hofmann, \{Oliver M\} and Jos{\'e}e Dupuis and Lu Qi and Segr{\`e}, \{Ayellet V\} and \{van Hoek\}, Mandy and Knut Borch-Johnsen and Kyvik, \{Kirsten Ohm\} and DIAGRAM Consortium",

year = "2012",

doi = "10.1371/journal.pone.0029202",

language = "English",

volume = "7",

journal = "PLoS ONE ",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "1",

}

Palmer, ND, McDonough, CW, Hicks, PJ, Roh, BH, Wing, MR, An, SS, Hester, JM, Cooke, JN, Bostrom, MA, Rudock, ME, Talbert, ME, Lewis, JP, Ferrara, A, Lu, L, Ziegler, JT, Sale, MM, Divers, J, Shriner, D, Adeyemo, A, Rotimi, CN, Ng, MCY, Langefeld, CD, Freedman, BI, Bowden, DW, Voight, BF, Scott, LJ, Steinthorsdottir, V, Morris, AP, Dina, C, Welch, RP, Zeggini, E, Huth, C, Aulchenko, YS, Thorleifsson, G, McCulloch, LJ, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, CJ, Raychaudhuri, S, McCarroll, SA, Langenberg, C, Hofmann, OM, Dupuis, J, Qi, L, Segrè, AV, van Hoek, M, Borch-Johnsen, K, Kyvik, KO & Consortium, DIAGRAM 2012, 'A genome-wide association search for type 2 diabetes genes in African Americans', PLoS ONE , bind 7, nr. 1, e29202. https://doi.org/10.1371/journal.pone.0029202

TY - JOUR

T1 - A genome-wide association search for type 2 diabetes genes in African Americans

AU - Palmer, Nicholette D

AU - McDonough, Caitrin W

AU - Hicks, Pamela J

AU - Roh, Bong H

AU - Wing, Maria R

AU - An, S Sandy

AU - Hester, Jessica M

AU - Cooke, Jessica N

AU - Bostrom, Meredith A

AU - Rudock, Megan E

AU - Talbert, Matthew E

AU - Lewis, Joshua P

AU - Ferrara, Assiamira

AU - Lu, Lingyi

AU - Ziegler, Julie T

AU - Sale, Michele M

AU - Divers, Jasmin

AU - Shriner, Daniel

AU - Adeyemo, Adebowale

AU - Rotimi, Charles N

AU - Ng, Maggie C Y

AU - Langefeld, Carl D

AU - Freedman, Barry I

AU - Bowden, Donald W

AU - Voight, Benjamin F

AU - Scott, Laura J

AU - Steinthorsdottir, Valgerdur

AU - Morris, Andrew P

AU - Dina, Christian

AU - Welch, Ryan P

AU - Zeggini, Eleftheria

AU - Huth, Cornelia

AU - Aulchenko, Yurii S

AU - Thorleifsson, Gudmar

AU - McCulloch, Laura J

AU - Ferreira, Teresa

AU - Grallert, Harald

AU - Amin, Najaf

AU - Wu, Guanming

AU - Willer, Cristen J

AU - Raychaudhuri, Soumya

AU - McCarroll, Steve A

AU - Langenberg, Claudia

AU - Hofmann, Oliver M

AU - Dupuis, Josée

AU - Qi, Lu

AU - Segrè, Ayellet V

AU - van Hoek, Mandy

AU - Borch-Johnsen, Knut

AU - Kyvik, Kirsten Ohm

AU - Consortium, DIAGRAM

PY - 2012

Y1 - 2012

N2 - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

AB - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

KW - Adult

KW - African Americans

KW - Aged

KW - Case-Control Studies

KW - Cohort Studies

KW - Diabetes Mellitus

KW - Type 2

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Male

KW - Meta-Analysis as Topic

KW - Middle Aged

KW - Polymorphism

KW - Single Nucleotide

KW - Validation Studies as Topic

U2 - 10.1371/journal.pone.0029202

DO - 10.1371/journal.pone.0029202

M3 - Article

SN - 1932-6203

VL - 7

JO - PLoS ONE

JF - PLoS ONE

IS - 1

M1 - e29202

ER -