A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Alisa K Manning; Marie-France Hivert; Robert A Scott; Jonna L Grimsby; Nabila Bouatia-Naji; Han Chen; Denis Rybin; Ching-Ti Liu; Lawrence F Bielak; Inga Prokopenko; Najaf Amin; Daniel Barnes; Gemma Cadby; Jouke-Jan Hottenga; Erik Ingelsson; Anne U Jackson; Toby Johnson; Stavroula Kanoni; Claes Ladenvall; Vasiliki Lagou; Jari Lahti; Cecile Lecoeur; Yongmei Liu; Maria Teresa Martinez-Larrad; May E Montasser; Pau Navarro; John R B Perry; Laura J Rasmussen-Torvik; Perttu Salo; Naveed Sattar; Dmitry Shungin; Rona J Strawbridge; Toshiko Tanaka; Cornelia M van Duijn; Ping An; Mariza de Andrade; Jeanette S Andrews; Thor Aspelund; Mustafa Atalay; Yurii Aulchenko; Beverley Balkau; Stefania Bandinelli; Jacques S Beckmann; John P Beilby; Claire Bellis; Richard N Bergman; John Blangero; Mladen Boban; Michael Boehnke; Kirsten Ohm Kyvik; DIAGRAM Consortium

doi:10.1038/ng.2274

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Alisa K Manning
, Marie-France Hivert
, Robert A Scott
, Jonna L Grimsby
, Nabila Bouatia-Naji
, Han Chen
, Denis Rybin
, Ching-Ti Liu
, Lawrence F Bielak
, Inga Prokopenko
, Najaf Amin
, Daniel Barnes
, Gemma Cadby
, Jouke-Jan Hottenga
, Erik Ingelsson
, Anne U Jackson
, Toby Johnson
, Stavroula Kanoni
, Claes Ladenvall
, Vasiliki Lagou

Jari Lahti, Cecile Lecoeur, Yongmei Liu, Maria Teresa Martinez-Larrad, May E Montasser, Pau Navarro, John R B Perry, Laura J Rasmussen-Torvik, Perttu Salo, Naveed Sattar, Dmitry Shungin, Rona J Strawbridge, Toshiko Tanaka, Cornelia M van Duijn, Ping An, Mariza de Andrade, Jeanette S Andrews, Thor Aspelund, Mustafa Atalay, Yurii Aulchenko, Beverley Balkau, Stefania Bandinelli, Jacques S Beckmann, John P Beilby, Claire Bellis, Richard N Bergman, John Blangero, Mladen Boban, Michael Boehnke, Kirsten Ohm Kyvik, DIAGRAM Consortium

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P

Originalsprog	Engelsk
Sider (fra-til)	659-669
Antal sider	11
Tidsskrift	Nature Genetics
Vol/bind	44
Udgave nummer	6
DOI	https://doi.org/10.1038/ng.2274
Status	Udgivet - 2012

Adgang til dokumentet

10.1038/ng.2274

Citationsformater

Manning, A. K., Hivert, M.-F., Scott, R. A., Grimsby, J. L., Bouatia-Naji, N., Chen, H., Rybin, D., Liu, C.-T., Bielak, L. F., Prokopenko, I., Amin, N., Barnes, D., Cadby, G., Hottenga, J.-J., Ingelsson, E., Jackson, A. U., Johnson, T., Kanoni, S., Ladenvall, C., ... Consortium, DIAGRAM. (2012). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics, 44(6), 659-669. https://doi.org/10.1038/ng.2274

@article{752613b07d664fb7949540c79dd4eb31,

title = "A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance",

abstract = "Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P ",

author = "Manning, \{Alisa K\} and Marie-France Hivert and Scott, \{Robert A\} and Grimsby, \{Jonna L\} and Nabila Bouatia-Naji and Han Chen and Denis Rybin and Ching-Ti Liu and Bielak, \{Lawrence F\} and Inga Prokopenko and Najaf Amin and Daniel Barnes and Gemma Cadby and Jouke-Jan Hottenga and Erik Ingelsson and Jackson, \{Anne U\} and Toby Johnson and Stavroula Kanoni and Claes Ladenvall and Vasiliki Lagou and Jari Lahti and Cecile Lecoeur and Yongmei Liu and Martinez-Larrad, \{Maria Teresa\} and Montasser, \{May E\} and Pau Navarro and Perry, \{John R B\} and Rasmussen-Torvik, \{Laura J\} and Perttu Salo and Naveed Sattar and Dmitry Shungin and Strawbridge, \{Rona J\} and Toshiko Tanaka and \{van Duijn\}, \{Cornelia M\} and Ping An and \{de Andrade\}, Mariza and Andrews, \{Jeanette S\} and Thor Aspelund and Mustafa Atalay and Yurii Aulchenko and Beverley Balkau and Stefania Bandinelli and Beckmann, \{Jacques S\} and Beilby, \{John P\} and Claire Bellis and Bergman, \{Richard N\} and John Blangero and Mladen Boban and Michael Boehnke and Kyvik, \{Kirsten Ohm\} and DIAGRAM Consortium",

year = "2012",

doi = "10.1038/ng.2274",

language = "English",

volume = "44",

pages = "659--669",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

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Manning, AK, Hivert, M-F, Scott, RA, Grimsby, JL, Bouatia-Naji, N, Chen, H, Rybin, D, Liu, C-T, Bielak, LF, Prokopenko, I, Amin, N, Barnes, D, Cadby, G, Hottenga, J-J, Ingelsson, E, Jackson, AU, Johnson, T, Kanoni, S, Ladenvall, C, Lagou, V, Lahti, J, Lecoeur, C, Liu, Y, Martinez-Larrad, MT, Montasser, ME, Navarro, P, Perry, JRB, Rasmussen-Torvik, LJ, Salo, P, Sattar, N, Shungin, D, Strawbridge, RJ, Tanaka, T, van Duijn, CM, An, P, de Andrade, M, Andrews, JS, Aspelund, T, Atalay, M, Aulchenko, Y, Balkau, B, Bandinelli, S, Beckmann, JS, Beilby, JP, Bellis, C, Bergman, RN, Blangero, J, Boban, M, Boehnke, M, Kyvik, KO & Consortium, DIAGRAM 2012, 'A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance', Nature Genetics, bind 44, nr. 6, s. 659-669. https://doi.org/10.1038/ng.2274

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AU - Manning, Alisa K

AU - Hivert, Marie-France

AU - Scott, Robert A

AU - Grimsby, Jonna L

AU - Bouatia-Naji, Nabila

AU - Chen, Han

AU - Rybin, Denis

AU - Liu, Ching-Ti

AU - Bielak, Lawrence F

AU - Prokopenko, Inga

AU - Amin, Najaf

AU - Barnes, Daniel

AU - Cadby, Gemma

AU - Hottenga, Jouke-Jan

AU - Ingelsson, Erik

AU - Jackson, Anne U

AU - Johnson, Toby

AU - Kanoni, Stavroula

AU - Ladenvall, Claes

AU - Lagou, Vasiliki

AU - Lahti, Jari

AU - Lecoeur, Cecile

AU - Liu, Yongmei

AU - Martinez-Larrad, Maria Teresa

AU - Montasser, May E

AU - Navarro, Pau

AU - Perry, John R B

AU - Rasmussen-Torvik, Laura J

AU - Salo, Perttu

AU - Sattar, Naveed

AU - Shungin, Dmitry

AU - Strawbridge, Rona J

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AU - van Duijn, Cornelia M

AU - An, Ping

AU - de Andrade, Mariza

AU - Andrews, Jeanette S

AU - Aspelund, Thor

AU - Atalay, Mustafa

AU - Aulchenko, Yurii

AU - Balkau, Beverley

AU - Bandinelli, Stefania

AU - Beckmann, Jacques S

AU - Beilby, John P

AU - Bellis, Claire

AU - Bergman, Richard N

AU - Blangero, John

AU - Boban, Mladen

AU - Boehnke, Michael

AU - Kyvik, Kirsten Ohm

AU - Consortium, DIAGRAM

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AB - Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P

U2 - 10.1038/ng.2274

DO - 10.1038/ng.2274

M3 - Article

SN - 1061-4036

VL - 44

SP - 659

EP - 669

JO - Nature Genetics

JF - Nature Genetics

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