TY - JOUR
T1 - A comparison of pediatric and adult neuromyelitis optica spectrum disorders
T2 - A review of clinical manifestation, diagnosis, and treatment
AU - Baghbanian, Seyed Mohammad
AU - Asgari, Nasrin
AU - Sahraian, Mohammad Ali
AU - Moghadasi, Abdorreza Naser
PY - 2018/5/15
Y1 - 2018/5/15
N2 - Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system (CNS). Serum immunoglobulin G autoantibodies (NMO-IgG) are identified in the majority of NMOSD patients. The Pediatric form presents before 18 years. Based on the similarity of clinical, neuroimaging, and laboratory characteristics of pediatric NMOSD to those of the adult form, the international panel suggested that adult criteria of NMOSD also are appropriate in pediatric patients. However, the proposed criteria need validation in pediatric patients. This strategy poses challenges to the study design in clinical trials in pediatric NMOSD patients.
AB - Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system (CNS). Serum immunoglobulin G autoantibodies (NMO-IgG) are identified in the majority of NMOSD patients. The Pediatric form presents before 18 years. Based on the similarity of clinical, neuroimaging, and laboratory characteristics of pediatric NMOSD to those of the adult form, the international panel suggested that adult criteria of NMOSD also are appropriate in pediatric patients. However, the proposed criteria need validation in pediatric patients. This strategy poses challenges to the study design in clinical trials in pediatric NMOSD patients.
KW - Neuromyelitis optica spectrum disorders - pediatric
UR - http://www.scopus.com/inward/record.url?scp=85042360275&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2018.02.028
DO - 10.1016/j.jns.2018.02.028
M3 - Review
C2 - 29478727
AN - SCOPUS:85042360275
SN - 0022-510X
VL - 388
SP - 222
EP - 231
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -