Many substances have oestrogenous effects, but both the strength and the character of the response induced by a certain ligand depend on a range of modifying factors. There are two variants of the oestrogen receptor, which bind different ligands with variable affinities and which differ in their ability to initiate expression from different genes. Moreover, the two receptor subtypes are expressed to different degrees in different tissues and cell types. At the same time, ligands induce unique changes in receptor conformation upon binding. The induced conformation is pivotal in the interaction with co-factors, as well as other transcription factors and DNA, and therefore also important in the initiation of transcription and the following cellular response. The occurrence of co-activators and co-repressors, as well as possible membrane-bound receptors, phosphorylation and local chromatin structure, play a role in mediating the oestrogen response as well.
|Bidragets oversatte titel||The molecular mechanisms of oestrogens: Clinical aspects, industrial estrogens and phytoestrogens|
|Tidsskrift||Ugeskrift for laeger|
|Status||Udgivet - 22 mar. 2004|